Next-Generation Sequencing in Translational Sarcoma Research: Biological Insights and Emerging Directions
Sarcomas are rare and heterogeneous malignancies for which molecular diagnostics increasingly complement histopathology, immunohistochemistry, FISH, and RT-PCR. This review summarizes the main research applications of next-generation sequencing (NGS) in sarcoma, with particular attention to mutation and variant discovery, fusion detection, biomarker development, assay validation, multi-omics integration, and the boundaries between exploratory research and clinical implementation.
- Veröffentlicht in:
Current Oncology Reports - Typ:
Article - Autoren:
- Jahr:
2026
Informationen zur Zitierung
: Next-Generation Sequencing in Translational Sarcoma Research: Biological Insights and Emerging Directions, Current Oncology Reports, 2026, 28, 1, September, Springer Science and Business Media LLC, DeVita.etal.2026a,
@Article{DeVita.etal.2026a,
author={De Vita, Alessandro; Violani, Sara; Miserocchi, Giacomo; Xerxa, Elena; Bajorath, Jürgen; Vanni, Silvia},
title={Next-Generation Sequencing in Translational Sarcoma Research: Biological Insights and Emerging Directions},
journal={Current Oncology Reports},
volume={28},
number={1},
month={September},
publisher={Springer Science and Business Media LLC},
year={2026},
abstract={Sarcomas are rare and heterogeneous malignancies for which molecular diagnostics increasingly complement histopathology, immunohistochemistry, FISH, and RT-PCR. This review summarizes the main research applications of next-generation sequencing (NGS) in sarcoma, with particular attention to mutation and variant discovery, fusion detection, biomarker development, assay validation, multi-omics...}}
