{"id":40879,"date":"2026-09-17T11:15:54","date_gmt":"2026-09-17T11:15:54","guid":{"rendered":"https:\/\/lamarr-institute.org\/publication\/automated-segmentation-and-length-measurement-of-metacarpal-and-phalangeal-bones-for-hand-radiograph-evaluation\/"},"modified":"2026-11-13T10:59:33","modified_gmt":"2026-11-13T10:59:33","slug":"automated-segmentation-and-length-measurement-of-metacarpal-and-phalangeal-bones-for-hand-radiograph-evaluation","status":"publish","type":"publication","link":"https:\/\/lamarr-institute.org\/de\/publication\/automated-segmentation-and-length-measurement-of-metacarpal-and-phalangeal-bones-for-hand-radiograph-evaluation\/","title":{"rendered":"Automated segmentation and length measurement of metacarpal and phalangeal bones for hand radiograph evaluation"},"content":{"rendered":"<p>Evaluating hand and wrist radiographs is essential in pediatric endocrinology and clinical genetics, particularly for the assessment of suspected skeletal anomalies. In this study, we present Auto-Bone-Caliper, an automated system for the segmentation and length measurement of metacarpal and phalangeal (M\\&#038;P) bones, trained and evaluated on public datasets comprising both normal and dysmorphic cases. We first introduce InstanceSAM, a two-stage framework that detects and segments all 19 M\\&#038;P bones in pediatric hand radiographs, achieving Dice scores of 98.7\\% for normal bones and 95.0\\% for dysmorphic bones. We further develop and evaluate three methods for bone-length estimation, identifying a k-means\u2013based approach as the most accurate, with relative errors of 2.2\\% for normal bones and 4.5\\% for dysmorphic bones. Our automated pipeline, Auto-Bone-Caliper, integrates InstanceSAM with the k-means\u2013based length-estimation method. To enable scale-independent downstream analyses, we derive relative bone-length measures from the automated measurements. Using these relative measures, we statistically compare measurements obtained using Auto-Bone-Caliper on an independent dataset with a healthy reference catalog of normal bone morphologies, observing a high level of agreement (Wasserstein-1 distance = 0.012). Finally, we demonstrate a potential clinical use case of Auto-Bone-Caliper by obtaining relative metacarpophalangeal pattern profiles for three genetic conditions, namely Turner syndrome, achondroplasia, and pseudohypoparathyroidism. Our results highlight the potential of the Auto-Bone-Caliper to streamline and standardize M\\&#038;P length measurement, providing an objective and reproducible tool suitable for clinical application.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Evaluating hand and wrist radiographs is essential in pediatric endocrinology and clinical genetics, particularly for the assessment of suspected skeletal anomalies. In this study, we present Auto-Bone-Caliper, an automated system for the segmentation and length measurement of metacarpal and phalangeal (M\\&#038;P) bones, trained and evaluated on public datasets comprising both normal and dysmorphic cases. We first introduce InstanceSAM, a two-stage framework that detects and segments all 19 M\\&#038;P bones in [&hellip;]<\/p>\n","protected":false},"author":14,"featured_media":0,"template":"","meta":{"_acf_changed":false,"footnotes":""},"publication-type":[30],"publication-year":[1680],"class_list":["post-40879","publication","type-publication","status-publish","hentry","publication-type-article","publication-year-1680"],"acf":[],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/lamarr-institute.org\/de\/wp-json\/wp\/v2\/publication\/40879","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lamarr-institute.org\/de\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/lamarr-institute.org\/de\/wp-json\/wp\/v2\/types\/publication"}],"author":[{"embeddable":true,"href":"https:\/\/lamarr-institute.org\/de\/wp-json\/wp\/v2\/users\/14"}],"version-history":[{"count":1,"href":"https:\/\/lamarr-institute.org\/de\/wp-json\/wp\/v2\/publication\/40879\/revisions"}],"predecessor-version":[{"id":43809,"href":"https:\/\/lamarr-institute.org\/de\/wp-json\/wp\/v2\/publication\/40879\/revisions\/43809"}],"wp:attachment":[{"href":"https:\/\/lamarr-institute.org\/de\/wp-json\/wp\/v2\/media?parent=40879"}],"wp:term":[{"taxonomy":"publication-type","embeddable":true,"href":"https:\/\/lamarr-institute.org\/de\/wp-json\/wp\/v2\/publication-type?post=40879"},{"taxonomy":"publication-year","embeddable":true,"href":"https:\/\/lamarr-institute.org\/de\/wp-json\/wp\/v2\/publication-year?post=40879"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}